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Currency [0]/Explanatory TextG5Explanatory Text % 0Good;Good  a%1 Heading 1G Heading 1 DTj%Dr2 Heading 2G Heading 2 DTj%?3 Heading 3G Heading 3 DTj%234 Heading 49 Heading 4 DTj% 5InputuInput ̙ ??v% 6 Linked CellK Linked Cell }% 7NeutralANeutral  W%3Normal % 8Noteb Note   9OutputwOutput  ???%????????? ???:$Percent ;Title1Title DTj% <TotalMTotal %DrDr= Warning Text? Warning Text %XTableStyleMedium2PivotStyleLight16`ASheet1,58 QuestionsDomainArbelaez et al. 2012Saad et al. 2012Smadja et al. 2013Ramos-Lopez et al. 2013Cao et al. 2014Buhren et al. 2014Chan et al. 2015Kovacs et al. 2016Saad et al. 2016Ruiz Hidalgo et al. 2016Ruiz Hidalgo et al. 2017Xu et al. 2017Ambrosio et al. 2017Sideroudi et al. 2017Francis et al. 2017Yousefi et al. 2018Lopes at al. 2018Steinberg et al. 2018Issarti et al. 2019Chandapura et al. 2019Xie at al. 2020Kuo et al. 2020Shi et al. 2020Toprak et al. 2020Issarti et al. 2020Lavric et al. 2020@Was a consecutive or random sample of patients enrolled? (N/Y/U)PATIENT SELECTIONNYU*Was a case-control design avoided? (N/Y/U)5Did the study avoid inappropriate exclusions? (N/Y/U)=Could the selection of patients have introduced bias? (H/L/U)HLYCould the conduct or interpretation of the index test have introduced bias? (H/L/U)REFERENCE STANDARDkWere the reference standard results interpreted without knowledge of the results of the index test? (N/Y/U)^Could the reference standard, its conduct, or its interpretation have introduced bias? (H/L/U)WWas there an appropriate interval between index test(s) and reference standard? (N/Y/U)FLOW AND TIMING6Did all patients receive a reference standard? (N/Y/U)=Did all patients receive the same reference standard? (N/Y/U)3Were all patients included in the analysis? (N/Y/U)4Could the patient flow have introduced bias? (H/L/U)N=NoY=Yes U=Unclear H=High Risk L=Low Risk INDEX TEST*Did the study perform external validation?TIs the reference standard likely to correctly classify the target condition? 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