@文章{信息:doi/10.2196/27816，作者=“Albalwy, Faisal and Brass, Andrew and Davies, Angela”，标题=“基于区块链的动态同意架构支持临床基因组数据共享(同意书链):概念验证研究”，期刊=“JMIR Med Inform”，年=“2021”，月=“11月”，日=“3”，卷=“9”，号=“11”，页=“e27816”，关键词=“区块链;聪明的合同;动态的同意;临床基因组学;背景:在临床基因组学中，基因数据库和实验室之间的罕见遗传疾病信息共享对于确定变异的致病意义，从而实现罕见遗传疾病的诊断至关重要。在实践中，对数据治理和安全的严重关注减少了这种共享。区块链可以提供一种在相关各方之间共享基因组数据的安全方法，从而帮助克服其中一些问题。目的:本研究旨在通过描述基于区块链的动态同意架构来支持临床基因组数据共享，并为架构提供概念验证实现(称为同意链)，以探索其性能，从而促进对区块链技术在支持临床基因组数据共享方面的潜在作用的日益增长的认识。方法:从患者论坛捕获同意书链需求，以确定安全性和同意书问题。ConsentChain是在以太坊平台上开发的，其中智能合约用于模拟患者的行为，患者可以提供或撤回共享数据的同意; the data creator, who collects and stores patient data; and the data requester, who needs to query and access the patient data. A detailed analysis was undertaken of the ConsentChain performance as a function of the number of transactions processed by the system. Results: We describe ConsentChain, a blockchain-based system that provides a web portal interface to support clinical genomic sharing. ConsentChain allows patients to grant or withdraw data requester access and allows data requesters to query and submit access to data stored in a secure off-chain database. We also developed an ontology model to represent patient consent elements into machine-readable codes to automate the consent and data access processes. Conclusions: Blockchains and smart contracts can provide an efficient and scalable mechanism to support dynamic consent functionality and address some of the barriers that inhibit genomic data sharing. However, they are not a complete answer, and a number of issues still need to be addressed before such systems can be deployed in practice, particularly in relation to verifying user credentials. ", issn="2291-9694", doi="10.2196/27816", url="https://medinform.www.mybigtv.com/2021/11/e27816", url="https://doi.org/10.2196/27816", url="http://www.ncbi.nlm.nih.gov/pubmed/34730538" }