应用移动健康App对幼儿神经发育障碍和产后抑郁症的早期检测卡塔尔世界杯8强波胆分析观察性横断面研究%A丹尼斯，法布里斯%A莫里耶，劳拉%A卡里略，凯文%A Ologeanu-Taddei，罗克莎娜%A Septans，安妮-莉斯%A Gepner，艾格尼丝%A Le Goff，弗洛里安%A Desbois,Madhu %A Demurger,Baptiste %A Silber，丹尼斯%A Zeitoun,Jean- david %A assued,Guedalia Peretz %A Bonnot,Olivier %+区域间Jean Bernard研究所，ELSAN，勒芒，72000，法国，330684190480，f.denis@ilcgroupe.fr %K早期检测%K NDD %K神经发育障碍%K ASD %K自闭症谱系障碍%K PND %K产后抑郁%K移动健康%K现实世界研究%K自闭症%K育儿%K儿科%K儿童%K手机%K智能手机%K移动健康应用程序%K数字健康干预%K数字产品%K算法%D 2022 %7 16.5.2022 %9原文% jjmir移动健康Uhealth %G英语%X幼儿神经发育障碍(ndd)和母亲产后抑郁症(PND)的诊断延迟是主要的公共卫生问题。在这两种情况下，早期干预都至关重要。目的:我们旨在评估一款名为Malo的移动应用程序是否可以减少NDD和PND的识别延迟。方法:我们在一组年轻父母中进行了一项观察性、横断面、基于数据的研究，这些父母在纳入时至少有一个3岁以下的孩子，并定期使用Malo。我们纳入了符合标准并同意在2021年11月11日至2022年1月14日之间参与的前4000名用户。父母每月通过这款应用接受问卷调查，评估婴儿的社交能力、听力、视力、运动能力、语言能力，以及可能的自闭症谱系障碍。母亲们也被要求在分娩后4-28周回答关于PND的定期问卷。 When any patient-reported outcomes matched predefined criteria, an in-app notification was sent to the user, recommending the booking of an appointment with their family physician or pediatrician. The main outcomes were the median age of the infant at the time of notification for possible NDD and the median time of PND notifications after childbirth. One secondary outcome was the relevance of the NDD notification for a consultation as assessed by the physicians. Results: Among 4242 children assessed by 5309 questionnaires, 613 (14.5%) had at least 1 disorder requiring a consultation. The median age of notification for possible autism spectrum, vision, audition, socialization, language, or motor disorders was 11, 9, 17, 12, 22, and 4 months, respectively. The sensitivity of the alert notifications of suspected NDDs as assessed by the physicians was 100%, and the specificity was 73.5%. Among 907 mothers who completed a PND questionnaire, highly probable PND was detected in 151 (16.6%) mothers, and the median time of detection was 8-12 weeks. Conclusions: The algorithm-based alert suggesting NDD was highly sensitive with good specificity as assessed by real-life practitioners. The app was also efficient in the early detection of PND. Our results suggest that the regular use of this multidomain familial smartphone app would permit the early detection of NDD and PND. Trial Registration: ClinicalTrials.gov NCT04958174; https://clinicaltrials.gov/ct2/show/NCT04958174 %M 35576565 %R 10.2196/38181 %U https://mhealth.www.mybigtv.com/2022/5/e38181 %U https://doi.org/10.2196/38181 %U http://www.ncbi.nlm.nih.gov/pubmed/35576565