一种交互式语音响应软件，改善乌干达艾滋病毒感染者的生活质量:卡塔尔世界杯8强波胆分析随机对照试验%A Byonanebye,Dathan Mirembe %A Nabaggala,Maria S %A Naggirinya,Agnes Bwanika %A Lamorde,Mohammed %A Oseku,Elizabeth %A King,Rachel %A Owarwo,Noela %A Laker,Eva %A Orama,Richard %A Castelnuovo,Barbara %A Kiragga,Agnes %A pares - ratanshi,Rosalind %+剑桥大学临床医学院剑桥公共卫生研究所，剑桥大学临床医学院，Forvie Site，剑桥生物医学校区，英国剑桥，44 7817739450，背景:在成功扩大抗逆转录病毒治疗(ART)之后，现在的重点是确保艾滋病毒感染者的良好生活质量(QoL)和持续的病毒抑制。在负担最重的国家，获得移动技术的机会正在迅速增加，因此，可以利用移动卫生技术改善艾滋病毒感染者的生活质量。然而，关于移动健康工具对艾滋病毒感染者生活质量影响的数据仅限于对短信短信的评估;这些在高文盲环境中是不可行的。目的:主要和次要结果是确定交互式语音响应(IVR)技术对12个月医疗结果研究HIV生活质量评分和病毒抑制的影响。方法:在呼吁生命的研究中，ART经历过和ART-naïve开始ART的艾滋病毒感染者随机(1:1比例)分为对照组(没有IVR支持)或干预组(每日坚持和预约前提醒、健康信息提示和报告症状的选项)。评估的软件是Call for Life Uganda，这是一种基于社区卫生移动技术开源软件的IVR技术。参与的资格标准包括使用电话、精通当地语言和获得同意。 The differences in differences (DIDs) were computed, adjusting for baseline HIV RNA and CD4. Results: Overall, 600 participants (413 female, 68.8%) were enrolled and followed-up for 12 months. In the intervention arm of 300 participants, 298 (99.3%) opted for IVR and 2 (0.7%) chose SMS text messaging as the mode of receiving reminders and health tips. At 12 months, there was no overall difference in the QoL between the intervention and control arms (DID=0.0; P=.99) or HIV RNA (DID=0.01; P=.94). At 12 months, 124 of the 256 (48.4%) active participants had picked up at least 50% of the calls. In the active intervention participants, high users (received >75% of reminders) had overall higher QoL compared to low users (received <25% of reminders) (92.2 versus 87.8, P=.02). Similarly, high users also had higher QoL scores in the mental health domain (93.1 versus 86.8, P=.008) and better appointment keeping. Similarly, participants with moderate use (51%-75%) had better viral suppression at 12 months (80/94, 85% versus 11/19, 58%, P=.006). Conclusions: Overall, there was high uptake and acceptability of the IVR tool. While we found no overall difference in the QoL and viral suppression between study arms, people living with HIV with higher usage of the tool showed greater improvements in QoL, viral suppression, and appointment keeping. With the declining resources available to HIV programs and the increasing number of people living with HIV accessing ART, IVR technology could be used to support patient care. The tool may be helpful in situations where physical consultations are infeasible, including the current COVID epidemic. Trial Registration: ClinicalTrials.gov NCT02953080; https://clinicaltrials.gov/ct2/show/NCT02953080 %M 33570497 %R 10.2196/22229 %U https://mhealth.www.mybigtv.com/2021/2/e22229 %U https://doi.org/10.2196/22229 %U http://www.ncbi.nlm.nih.gov/pubmed/33570497