@文章{信息:doi/10.2196/32203，作者=“Akhtar, Hashaam和Khalid, Sundas和Rahman, Fazal ur和Umar, Muhammad和Ali, Sabahat和Afridi, Maham和Hassan, Faheem和Saleh Khader, Yousef和Akhtar, Nasim和Khan, Muhammad Mujeeb和Ikram, Aamer”，标题=“巴基斯坦住院的COVID-19患者的表现特征、共病和结局:回顾性观察研究”，期刊=“JMIR公共卫生监测”，年=“2021”，月=“12”，日=“14”，卷=“7”，数=“12”，页=“e32203”，关键词=“COVID-19;指标;症状;风险因素;并发症;严重程度;背景:2019年12月COVID-19出现后迅速成为大流行。它属于冠状病毒家族，历史上曾发生过几次。基于先前关于该家族其他病毒的病因学和流行病学研究的数据，有助于在本次大流行的初始阶段制定预防和预防战略。 Data related to COVID-19 in Pakistan were not initially documented on a large scale. In addition, due to a weak health care system and low economic conditions, Pakistan's population, in general, already suffers from many comorbidities, which can severely affect the outcome of patients infected with COVID-19. Objective: COVID-19 infections are coupled with a manifestation of various notable outcomes that can be documented and characterized clinically. The aim of this study was to examine these clinical manifestations, which can serve as indicators for early detection as well as severity prognosis for COVID-19 infections, especially in high-risk groups. Methods: A retrospective observational study involving abstraction of demographic features, presenting symptoms, and adverse clinical outcomes for 1812 patients with COVID-19 was conducted. Patients were admitted to the four major hospitals in the Rawalpindi-Islamabad region of Pakistan, and the study was conducted from February to August 2020. Multivariate regression analysis was carried out to identify significant indicators of COVID-19 severity, intensive care unit (ICU) admission, ventilator aid, and mortality. The study not only relates COVID-19 infection with comorbidities, but also examines other related factors, such as age and gender. Results: This study identified fever (1592/1812, 87.9{\%}), cough (1433/1812, 79.1{\%}), and shortness of breath (998/1812, 55.1{\%}) at the time of hospital admission as the most prevalent symptoms for patients with COVID-19. These symptoms were common but not conclusive of the outcome of infection. Out of 1812 patients, 24.4{\%} (n=443) required ICU admission and 21.5{\%} (n=390) required ventilator aid at some point of disease progression during their stay at the hospital; 25.9{\%} (n=469) of the patients died. Further analysis revealed the relationship of the presented symptoms and comorbidities with the progression of disease severity in these patients. Older adult patients with comorbidities, such as hypertension, diabetes, chronic kidney disease, and asthma, were significantly affected in higher proportions, resulting in requirement of ICU admission and ventilator aid in some cases and, in many cases, even mortality. Conclusions: Older adult patients with comorbidities, such as hypertension, diabetes, asthma, chronic obstructive pulmonary disorder, and chronic kidney disease, are at increased risk of developing severe COVID-19 infections, with an increased likelihood of adverse clinical outcomes. ", issn="2369-2960", doi="10.2196/32203", url="https://publichealth.www.mybigtv.com/2021/12/e32203", url="https://doi.org/10.2196/32203", url="http://www.ncbi.nlm.nih.gov/pubmed/34710053" }