临床严重程度与SARS-CoV-2 δ型变异潜伏期的关系卡塔尔世界杯8强波胆分析香港中文大学公共卫生及初级保健学院王a、栾凯、郭泽民、冉子豪、田金军、赵茂泽、石+ JC回顾性观察研究，香港银城街30-32号威尔斯亲王医院公共卫生大楼417室(香港)，852 22528865zhaoshi.cmsa@gmail.com %K COVID-19 %K δ变异%K潜伏期%K临床严重程度%K中国%D 2022 %7 18.11.2022 %9公共卫生监测背景:截至2021年8月25日，江苏省经历了中国东部地区最大的由SARS-CoV-2 δ变异播撒的COVID-19疫情。潜伏期是表征COVID-19传播动态的关键流行病学参数之一，对公共卫生防控措施具有重要意义。COVID-19的潜伏期可能因年龄、性别、疾病严重程度和研究环境而异。然而，这些因素对Delta变异潜伏期的影响仍未得到研究。目的:本研究的目的是利用详细的接触者追踪数据来描述德尔塔病毒变体的潜伏期。采用多因素回归分析和亚组分析，探讨年龄、性别和疾病严重程度对潜伏期的影响。方法:提取江苏省2021年7 - 8月353例SARS-CoV-2 δ型实验室确诊病例的接触者追踪数据。利用基于似然的方法对区间截除观测值进行调整，估计了δ变异潜伏期的分布。 The effects of age, sex, and disease severity on the incubation period were expiated by using multivariate logistic regression model with interval censoring. Results: The mean incubation period of the Delta variant was estimated at 6.64 days (95% credible interval: 6.27-7.00). We found that female cases and cases with severe symptoms had relatively longer mean incubation periods than male cases and those with nonsevere symptoms, respectively. One-day increase in the incubation period of Delta variants was associated with a weak decrease in the probability of having severe illness with an adjusted odds ratio of 0.88 (95% credible interval: 0.71-1.07). Conclusions: In this study, the incubation period was found to vary across different levels of sex, age, and disease severity of COVID-19. These findings provide additional information on the incubation period of Delta variants and highlight the importance of continuing surveillance and monitoring of the epidemiological characteristics of emerging SARS-CoV-2 variants as they evolve. %M 36346940 %R 10.2196/40751 %U https://publichealth.www.mybigtv.com/2022/11/e40751 %U https://doi.org/10.2196/40751 %U http://www.ncbi.nlm.nih.gov/pubmed/36346940