中国50岁以上人群中抑郁症状和体力活动水平在HIV感染状态与神经认知功卡塔尔世界杯8强波胆分析能之间的中介作用jlau@cuhk.edu.hk %K神经认知表现%K HIV血清状态%K抑郁症状%K体力活动水平%K中介效应%K HIV %K抑郁%K体力活动%K神经认知%K心理健康%K公共卫生%D 2022 %7 JMIR公共卫生监测研究背景:神经认知障碍在中国老年人中普遍存在。在感染艾滋病毒的老年人中，这一问题更为严重。目的:本研究旨在比较老年HIV感染者和HIV阴性对照组的神经认知表现，并探讨HIV状态与神经认知表现之间的关联是否通过抑郁症状和身体活动水平介导。方法:在中国永州进行横断面研究。所有登记在册的年龄≥50岁的艾滋病毒感染者都被邀请。根据老年艾滋病毒感染者的年龄、性别和受正规教育年限分布，使用频率匹配从一般人群中抽取艾滋病毒阴性对照。共有315名老年艾滋病毒感染者和350名艾滋病毒阴性对照者完成了面对面访谈和7个领域(学习、记忆、工作记忆、语言流畅性、处理速度、执行功能和运动技能)的综合神经心理学评估。结果:与艾滋病毒阴性对照相比，老年艾滋病毒感染者在全球得分和所有七个领域的表现更差(P< 0.05)。 HIV infection was associated with higher depressive symptoms (P<.001) and lower level of physical activity (P<.001). Depressive symptoms and physical activity were negatively correlated (P<.001). Depressive symptoms and level of physical activity mediated the association between HIV status and global z-score and four domain z-scores of neurocognitive performance (learning, memory, verbal fluency, and processing speed). Conclusions: Change in mental health and physical activity after HIV infection may partially explain why older people living with HIV are more susceptible to neurocognitive impairment. Promoting mental health and physical activity are potential entry points to slow down the progress of neurocognitive impairment among older people living with HIV. %M 35984684 %R 10.2196/32968 %U https://publichealth.www.mybigtv.com/2022/8/e32968 %U https://doi.org/10.2196/32968 %U http://www.ncbi.nlm.nih.gov/pubmed/35984684