期刊文章JMIR出版物The Anatomy of SARS-CoV-卡塔尔世界杯8强波胆分析2生物医学文献:* * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * *ahamed@norwich.edu %K健康%K信息学%K COVID-19治疗%K药物再利用%K网络算法%K排名%K药物%K生物医学%K抗病毒%K COVID-19 %D 2020 %7 20.8.2020 %9背景:受COVID-19大流行和发现抗病毒药物的迫切需要的驱动，我们探索了SARS-CoV-2生物医学出版物的格局，以确定潜在的治疗方法。目的:本研究的目的是识别可能对冠状病毒疾病大流行有益的超说明书药物，提出一种名为CovidX的新型排名算法，推荐现有药物用于潜在的再利用，并利用临床试验中可用的药物知识验证基于文献的结果。方法:为了实现这一目标，我们应用自然语言处理技术来识别药物和相关实体(如疾病、基因、蛋白质、化合物)。当这些实体连接起来时，它们就形成了一张地图，可以使用网络科学工具进一步探索。covid - x算法基于我们称之为“多样性”的概念。给定药物的多样性分数是通过测量使用各种生物实体计算药物的“多样性”程度来计算的(不管每个类别中实际实例的基数)。该算法验证排名，并奖励那些目前正在公开临床试验中进行研究的药物。公开临床试验背后的基本原理是提供PubMed结果的验证机制。 This ensures providing up to date evidence of the fast development of this disease. Results: From the analyzed biomedical literature, the algorithm identified 30 possible drug candidates for repurposing, ranked them accordingly, and validated the ranking outcomes against evidence from clinical trials. The top 10 candidates according to our algorithm are hydroxychloroquine, azithromycin, chloroquine, ritonavir, losartan, remdesivir, favipiravir, methylprednisolone, rapamycin, and tilorone dihydrochloride. Conclusions: The ranking shows both consistency and promise in identifying drugs that can be repurposed. We believe, however, the full treatment to be a multifaceted, adjuvant approach where multiple drugs may need to be taken at the same time. %M 32735546 %R 10.2196/21169 %U //www.mybigtv.com/2020/8/e21169/ %U https://doi.org/10.2196/21169 %U http://www.ncbi.nlm.nih.gov/pubmed/32735546

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