使用智能手机击键动态被动监测多发性硬化症患者上肢和认知功能:卡塔尔世界杯8强波胆分析纵向分析%A Lam,Ka-Hoo %A Twose,James %A Lissenberg-Witte,Birgit %A Licitra,Giovanni %A Meijer,Kim %A Uitdehaag,Bernard %A De Groot,Vincent %A Killestein,Joep %+阿姆斯特丹大学医学中心(VU大学医学中心所在地)，De Boelelaan 1117，阿姆斯特丹，1081HV，荷兰，31 204440717，k.lam1@amsterdamumc.nl %K多发性硬化症%K智能手机%K移动应用程序%K数字技术%K击键动力学%K打字%K上肢%K认知%K门诊监测%D 2022 %7 7.11.2022 %9原文%J J Med互联网Res %G英语%X背景:在智能手机上打字已经成为一种近乎日常的活动，对上肢和认知功能都有要求。因此，对常规打字过程中键盘交互的分析，即击键动力学，可以潜在地用于多发性硬化症患者的被动和持续功能监测。目的:为了确定被动获得的智能手机按键动力学是否与多发性硬化症结果相对应，我们研究了按键动力学与临床结果(上肢和认知功能)之间的关系。为了研究独立于患者之间差异的患者内部变化，对这种关联进行了纵向调查。方法:对102例多发性硬化症患者进行为期1年的随访，每3个月分别用九孔钉测试和符号数字模式测试评估手臂功能和信息处理速度。敲击键盘动力学数据是通过参与者在自己的智能手机上定期打字而连续获得的。字母数字键的按键释放潜伏期构成精细运动分簇，标点键和退格键的按键释放潜伏期构成认知分簇。使用线性混合模型评估击键簇与相应临床结果之间随时间的关系，受试者作为随机截距。 By centering around the mean and calculating deviation scores within subjects, between-subject and within-subject effects were distinguished. Results: Mean (SD) scores for the fine motor score cluster and cognition score cluster were 0.43 (0.16) and 0.94 (0.41) seconds, respectively. The fine motor score cluster was significantly associated with the Nine-Hole Peg Test: between-subject β was 15.9 (95% CI 12.2-19.6) and within-subject β was 6.9 (95% CI 2.0-11.9). The cognition score cluster was significantly associated with the Symbol Digit Modalities Test between subjects (between-subject β –11.2, 95% CI –17.3 to –5.2) but not within subjects (within-subject β –0.4, 95% CI –5.6 to 4.9). Conclusions: Smartphone keystroke dynamics were longitudinally associated with multiple sclerosis outcomes. Worse arm function corresponded with longer latency in typing both across and within patients. Worse processing speed corresponded with higher latency in using punctuation and backspace keys across subjects. Hence, keystroke dynamics are a potential digital biomarker for remote monitoring and predicting clinical outcomes in patients with multiple sclerosis. Trial Registration: Netherlands Trial Register NTR7268; https://trialsearch.who.int/Trial2.aspx?TrialID=NTR7268 %M 36342763 %R 10.2196/37614 %U //www.mybigtv.com/2022/11/e37614 %U https://doi.org/10.2196/37614 %U http://www.ncbi.nlm.nih.gov/pubmed/36342763