TY -的AU -马歇尔,内尔J AU -李,Jennifer L AU -施罗德杰西卡AU -李,Wei-Nchih盟——看,杰明盟博盖,默罕默德盟——Munagala Mrudula R AU -移液管,约翰•D AU - Tan Litjen盟——Vardeny奥利AU -格林伯格(Michael盟——一天,1月盟-美世,莫妮卡盟,参孙Sandrine PY - 2022 DA - 2022/10/7 TI -数字干预消息对流感疫苗接种率与心血管疾病在美国成年人中:分散随机对照试验-流感-随机试验-公共卫生-心血管疾病-免疫-接种-数字信息-数字干预-移动健康-移动健康-背景:季节性流感每年影响5%至15%的美国人，导致可预防的死亡和重大的经济影响。流感感染对心血管疾病患者尤其危险，因此他们是疫苗接种运动的重点群体。目的:我们旨在评估数字干预信息对自我报告的季节性流感疫苗接种率的影响。方法:这是一项随机、对照、单盲、分散的试验，于2020-2021年流感季节在美国各地进行。作为Achievement移动平台的成员，自我报告患有心血管疾病的成年人随机接受或不接受一系列6个以患者为中心的促进流感疫苗接种的数字干预信息。主要终点是随机分组后6个月自我报告的疫苗接种率的组间差异。次要结果包括参与信息的水平以及疫苗接种率与参与信息之间的关系。亚组分析考察了不同种族干预效果的差异。在随机分组的控制下，我们检查了疫苗接种状况的其他预测因素的影响，包括心血管疾病类型、疫苗驱动因素或障碍以及疫苗知识。 Results: Of the 49,138 randomized participants, responses on the primary end point were available for 11,237 (22.87%; 5575 in the intervention group and 5662 in the control group) participants. The vaccination rate was significantly higher in the intervention group (3418/5575, 61.31%) than the control group (3355/5662, 59.25%; relative risk 1.03, 95% CI 1.004-1.066; P=.03). Participants who were older, more educated, and White or Asian were more likely to report being vaccinated. The intervention was effective among White participants (P=.004) but not among people of color (P=.42). The vaccination rate was 13 percentage points higher among participants who completed all 6 intervention messages versus none, and at least 2 completed messages appeared to be needed for effectiveness. Participants who reported a diagnosis of COVID-19 were more likely to be vaccinated for influenza regardless of treatment assignment. Conclusions: This personalized, evidence-based digital intervention was effective in increasing vaccination rates in this population of high-risk people with cardiovascular disease. Trial Registration: ClinicalTrials.gov NCT04584645; https://clinicaltrials.gov/ct2/show/NCT04584645 SN - 1438-8871 UR - //www.mybigtv.com/2022/10/e38710 UR - https://doi.org/10.2196/38710 UR - http://www.ncbi.nlm.nih.gov/pubmed/36206046 DO - 10.2196/38710 ID - info:doi/10.2196/38710 ER -